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Cellulitis With HS: How To Differentiate From a Flare

Medically reviewed by Nahla Maher, M.D.
Written by Sarah Winfrey
Updated on October 5, 2026

Key Takeaways

  • Hidradenitis suppurativa (HS) and cellulitis are two conditions that can be hard to tell apart, since they share some similar symptoms like pain, swelling, and skin discoloration.
  • People with HS can develop cellulitis when bacteria enter the skin through open sores or abscesses, and if left untreated, cellulitis can lead to a serious condition called sepsis, which affects the whole body. Some signs that may point to cellulitis rather than an HS flare include streaks on the skin, dimpling, a spreading rash, and fever.
  • If you notice symptoms that seem more severe than usual, like a fever, rapidly spreading redness, or skin that is extremely tender, it is important to reach out to a healthcare provider right away so they can help you figure out the best path forward for your care.
  • View all takeaways

When hidradenitis suppurativa (HS) symptoms flare up, you may experience a fever and skin that seems infected. As a result, it’s not always easy to tell if you’re dealing with cellulitis (a skin infection), an HS flare, or both.

Read on to learn what cellulitis is and how it can develop as a complication of HS. You’ll also discover some ways cellulitis and HS symptoms differ. As always, your dermatologist or healthcare provider is your best resource for questions about your skin.

What Causes Cellulitis With HS?

Cellulitis happens when bacteria (usually staphylococcus or streptococcus) enter the skin. Any break — even a tiny one — in the skin can lead to this infection.

People with HS can develop cellulitis because they often have open sores on or near their abscesses (inflamed pockets of fluid-filled skin). These areas can provide entry points for infection-causing bacteria.

Cellulitis infections go beyond the surface level of the skin. Tunnels (also known as sinus tracts), lesions, and abscesses in people with HS can provide bacteria the perfect opportunity to go deep into the skin and cause a serious infection.

However, just because HS lesions contain pus or bacteria doesn’t mean they’re infected. Open wounds increase the risk of infection, but HS tunnels and drainage don’t always lead to cellulitis.

🗳️ Have you ever struggled to tell the difference between an HS lesion and cellulitis?
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What Does Cellulitis Feel Like With HS?

Cellulitis can seriously impact your sense of well-being and quality of life. This is especially true when your symptoms last a long time or keep coming back.

If left untreated, cellulitis can lead to sepsis. This potentially life-threatening condition is an extreme response to an infection. The chain reaction that happens in your body during sepsis can lead to organ failure.

Several myHSteam members have experienced sepsis firsthand. “I ended up in the hospital last week with cellulitis and sepsis due to HS,” shared one member. “I had to be put on IV antibiotics! It was a scary experience.”

Symptoms of Cellulitis vs. HS Symptoms

HS causes painful nodules in areas of the body with sweat glands, such as the armpits and genitals. Some symptoms of cellulitis and HS overlap, so it can be hard to know the difference.

HS causes pain, swelling, discoloration, and skin tenderness. People with HS have to monitor any flare-ups, abscesses, or boils carefully and keep in mind what’s normal for them.

If you have HS, you should also watch for several particular symptoms that may point to cellulitis. If your skin looks or feels more severe or painful than usual, tell your doctor. It’s always better to ask for help you don’t need than to potentially end up with a serious infection.

Extremely Tender Skin

Tender skin can be a warning sign that cellulitis or an HS flare may be coming.

People living with HS experience painful cysts on their skin. Cellulitis can also cause pain and tenderness. With either condition, it may feel impossible to wear even light clothing or feel minimal friction against the skin.

Streaks or Dimpling

Cellulitis can cause streaks on the skin. These discolored lines may radiate from the main rash when nearby lymphatic vessels become inflamed, which is called lymphangitis. However, since streaks don’t always happen, their absence can’t rule out cellulitis.

In addition, cellulitis may affect the skin’s texture. Affected areas can have pitting or dimpling, like an orange peel. Although HS symptoms vary from person to person, dimpling isn’t considered a common sign of HS.

Swelling and Discoloration

People with HS are no strangers to swelling and discoloration. Your skin may become warm and red or discolored, depending on your normal skin tone. But if the affected area is spreading, you should seek medical attention.

Doctors and dermatology specialists recommend drawing a circle around a discolored, swollen area when you first notice it. If the border of the affected area continues expanding beyond the circle, the cause could be cellulitis or another issue.

Fever

An elevated temperature is possible during an HS flare since HS is driven by inflammation. But a fever is also a common sign of cellulitis and other infections.

If you have a fever, chills, or rapidly spreading redness or discolored skin, contact a healthcare professional right away.

How Is Cellulitis Treated?

If you suspect you have cellulitis, discuss treatment options with your healthcare provider. Cellulitis can lead to potentially deadly conditions like sepsis, so it’s crucial to seek medical treatment as soon as possible.

Treatment options may include:

  • Antibiotics that you take by mouth
  • Antibiotics that are given through an IV line
  • Surgery (in rare and severe cases)

Treatment of Hidradenitis Suppurativa

HS can be difficult to treat. But if you can find an effective treatment strategy that keeps your HS symptoms in check, you may be less likely to develop skin infections like cellulitis. That’s because keeping HS under control can help reduce open sores, drainage, and other complications that can lead to infection.

Members of myHSteam have shared their stories and challenges. One member said, “I have severe folliculitis and cellulitis, which antibiotics aren’t clearing. Honestly, I’m at the end of my tether. I cannot cope.”

Another shared, “About two years ago, I had a really bad ‘flare-up’ in my buttocks area that ended up bursting and sending me to the ER. The doctors said it was cellulitis, and I was hospitalized for three days.”

“I’m in terrible pain, as I have an infected boil in my armpit and have now developed cellulitis. I’m currently on antibiotics and bathing three to four times a day. I hope it opens and drains soon,” another member wrote.

Hearing what others have gone through can help you feel less alone when life with HS gets tough. Remember, you have several options to help manage HS flares and complications. An experienced dermatologist can help you find what works for you.

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A myHSteam Member

I've had cellulitis several times with my HS. Two times (so far) I've had surgery under general anesthesia to debride the areas. The first surgery was in my groin, took a large, deep chunk out and… read more

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