Hyrimoz (Adalimumab-Adaz) for Hidradenitis Suppurativa

Hyrimoz (adalimumab-adaz) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe hidradenitis suppurativa in people 12 years of age and older.

How Hyrimoz Works and How It’s Taken

Hyrimoz works by blocking a protein in the body called tumor necrosis factor (TNF). This protein plays a role in inflammation, which is the body’s response to injury or infection.

By blocking TNF, Hyrimoz can help reduce inflammation linked to hidradenitis suppurativa. The exact way it works in the body is not fully known.

Doctors prescribe Hyrimoz to patients with moderate to severe hidradenitis suppurativa who are age 12 or older. It is given as an injection under the skin. Treatment starts with higher doses at the beginning, followed by regular doses.

These doses are usually given every week or every other week. After proper training, people or caregivers may give the injections at home.

Hyrimoz Side Effects

In clinical studies of Hyrimoz (adalimumab-adaz) for moderate to severe hidradenitis suppurativa in people 12 years of age and older, the most common side effect was:

Injection site reaction (such as discoloration, itching, bruising, pain, or swelling where you inject)

Serious Side Effects and Warnings

Hyrimoz can cause serious side effects that require immediate medical attention. These include:

Serious infections — Your immune system may not fight infections as well, including tuberculosis, invasive fungal infections, and other serious bacterial or viral infections.
Cancer — This may include lymphoma and other cancers.
Severe allergic reactions — These may include anaphylaxis or angioedema, which can cause swelling and trouble breathing.
Hepatitis B virus reactivation — The virus can become active again in people who carry it.
Nervous system problems — These may include rare demyelinating disorders, which affect the protective covering of nerves, such as multiple sclerosis, optic neuritis, or Guillain-Barré syndrome.
Blood problems — These may include rare but serious low blood cell counts, which can cause easy bruising, bleeding, or persistent fever.
Heart failure — This may include new or worsening congestive heart failure.
Autoimmune reactions — These may include lupuslike syndrome or autoimmune hepatitis.
Serious liver problems — These may include hepatitis or, rarely, liver failure.
Severe skin reactions — These may include Stevens-Johnson syndrome, erythema multiforme, or new or worsening psoriasis.

Get medical help right away if you think you are having a serious reaction.

How To Save on Hyrimoz

Sandoz, the manufacturer of Hyrimoz, offers the Sandoz One Source Co-Pay Program for Hyrimoz. Eligible people with commercial insurance may pay as little as $0 per treatment. If you have government insurance or no insurance, the website offers information on other ways to save on your prescription.

The Sandoz One Source Co-Pay Program also offers a dedicated support team to assist you with reimbursement and financial assistance, injection services, and educational materials. To learn more, visit the Hyrimoz patient transition program, or call or text “COPAY” to 833-497-4669.

What To Know Before Taking Hyrimoz

Before starting Hyrimoz, your doctor will check you for active tuberculosis (TB), hidden (latent) TB, and may also test for hepatitis B (a virus that affects the liver).

People taking Hyrimoz can get most vaccines, but they should not get live vaccines. Children should be up to date on their vaccines before starting treatment, if possible.

Tell your doctor if you have any allergies to adalimumab-adaz or any ingredients in Hyrimoz.

Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.

Tell your doctor if you have an infection, have had frequent infections, or plan to travel to places where certain infections are more common. Also tell your doctor if you have had cancer or problems with your nervous system.

Hyrimoz is also FDA approved to treat rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, and noninfectious intermediate, posterior, and panuveitis.

If you miss a dose, take it as soon as you remember. Then take your next dose at your usual time.

If you are pregnant, planning to become pregnant, or breastfeeding while taking Hyrimoz, talk with your doctor about the risks and benefits.

Community FAQs

These answers are fact-checked by our editorial staff.

How effective is Hyrimoz in hidradenitis suppurativa?
In clinical studies, adalimumab, the reference product for Hyrimoz, was studied in people with hidradenitis suppurativa. The safety profile in people with hidradenitis suppurativa was consistent with the known safety profile of adalimumab.

In these studies, about 22 out of 100 people who stopped treatment after the main study period experienced a flare, which means their condition got worse. These results suggest that continuing treatment may help keep symptoms under control for some people.

How often is Hyrimoz taken for hidradenitis suppurativa?
Hyrimoz is first given as higher starting doses. This includes 160 milligrams on day 1. This dose may be given in one day or split over two days.

This is followed by 80 milligrams on day 15. Starting on day 29, Hyrimoz is taken regularly as either 40 milligrams every week or 80 milligrams every other week.

For adolescents 12 years of age and older, the dose is based on body weight and follows the recommended schedule.

Should I take Hyrimoz for hidradenitis suppurativa if I have an infection?
No. Do not start Hyrimoz if you have an active infection, especially one that is serious or getting worse.

Hyrimoz can increase the risk of infections. If you develop an infection during treatment, your doctor will monitor you and may stop Hyrimoz if the infection becomes serious.

Before starting, your doctor will check for infections such as tuberculosis and may test for hepatitis B. During treatment, watch for signs like fever, cough, or feeling unwell, and contact your doctor if they occur.