Hulio (Adalimumab-Fkjp) for Hidradenitis Suppurativa

Hulio (adalimumab-fkjp) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with moderate to severe hidradenitis suppurativa.

How Hulio Works and How It’s Taken

Hulio works by blocking a protein in the body called tumor necrosis factor (TNF). TNF plays a role in causing inflammation, which is swelling and irritation in the body.

By blocking TNF, Hulio can help reduce inflammation linked to painful lumps and tunnels under the skin. The exact way it works is not fully known.

Doctors prescribe Hulio when someone has moderate to severe hidradenitis suppurativa. The medicine is given as an injection under the skin.

Treatment starts with higher doses at the beginning, followed by regular doses every week or every other week. If a doctor says it is OK, people or caregivers can give the injections at home after they are trained.

Hulio Side Effects

In clinical studies of Hulio (adalimumab-fkjp) for moderate to severe hidradenitis suppurativa in adults, the most common side effects that occurred were:

Injection-site reactions (discoloration, itching, bleeding, pain, or swelling where you inject)
Infections (such as upper respiratory infections and sinus infections)
Headache
Rash

Serious Side Effects and Warnings

Hulio can cause serious side effects that require immediate medical attention. These include:

Serious infections — Your immune system may not fight infections as well, including tuberculosis, invasive fungal infections, and other bacterial or viral infections that can spread.
Cancer, including lymphoma and certain skin cancers — The chance of some cancers may increase.
Severe allergic reactions, including anaphylaxis and angioedema — These can cause swelling and trouble breathing.
Hepatitis B reactivation — The hepatitis B virus can become active again in people who carry it.
Nervous system problems — Rare demyelinating disorders, such as optic neuritis, multiple sclerosis, or Guillain-Barré syndrome, may develop.
Blood disorders — Rare but serious low blood cell counts may cause easy bruising, bleeding, or persistent fever.
Heart failure — New or worsening congestive heart failure may occur.
Lupus-like syndrome — An autoimmune reaction that can cause symptoms similar to lupus could develop.

Get medical help right away if you think you are having a serious reaction.

How To Save on Hulio

Biocon Biologics, the manufacturer of Hulio, offers the HULIO360 Copay Assistance Program under My Biocon Biologics. Eligible people with commercial insurance may pay as little as $0 for each monthly fill of Hulio.

My Biocon Biologics also offers clinical and administrative support, including nurse-led injection training, help with prior authorization, and resources to support treatment adherence and help patients manage their Hulio therapy.

To learn more, visit the My Biocon Biologics services and support page or call 833-612-4626.

What To Know Before Taking Hulio

Before starting Hulio, your doctor will check you for active tuberculosis (TB) and hidden (latent) TB and may also test for hepatitis B (a virus that affects the liver). Do not start Hulio if you have an active infection.

Before starting Hulio, make sure your vaccines are up to date, and do not receive live vaccines while taking Hulio.

Tell your doctor if you have any allergies to adalimumab-fkjp or any ingredients in Hulio.

Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.

Also let your doctor know if you have had infections, plan to travel to areas where certain infections are common, or have had cancer or nervous system problems.

There are no listed contraindications for Hulio in the prescribing information.

Hulio is also FDA approved to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, and uveitis.

If you miss a dose, take it as soon as you remember. Then go back to your regular dosing schedule.

If you are pregnant, planning to become pregnant, or breastfeeding while taking Hulio, talk with your doctor about the risks and benefits.

Community FAQs

How effective is Hulio?
In clinical studies, adalimumab, the reference product for Hulio, was studied in people with hidradenitis suppurativa. The safety profile in people with hidradenitis suppurativa was consistent with the known safety profile of adalimumab.

In two studies, about 22 out of 100 people who stopped treatment after the main study period experienced a flare (worsening) of their condition. These results suggest that staying on treatment may help keep symptoms under control for some people.

Should I take Hulio for HS if I have an infection?
You should not start Hulio if you have an active infection. This medication can weaken your immune system, which may make infections worse.

Talk to your doctor right away if you develop signs of infection during treatment.

What tests or monitoring are needed with Hulio for HS?
Before starting Hulio, your doctor will check you for tuberculosis. This includes testing for active TB and hidden (latent) TB.

Your doctor may also test for hepatitis B, which is a virus that affects the liver, especially if you are at risk. During treatment, your doctor will monitor you for signs of infection or other side effects.